Association between adiponectin with insulin and blood sugar levels in obese adolescents in comparison with normal weight adolescents

Introduction: The growing number of obesity and excess of body fat mass in adolescents in recent years and also increasing prevalence of chronic diseases associated with obesity in Iranian adolescents, tends to develop this study. The present was aimed to investigate relationship between adiponectin level with some of biochemical and anthropometric index in obese and normal weight adolescents. Methods: In this cross-sectional study, 76 healthy non-athlete and non-smoker adolescent girls, without any history of chronic, inflammatory, infectious, metabolic and endocrine diseases, without taking any drugs or supplements were investigated. They were divided in 2 groups by Iranian BMI percentile criteria according to their age and sex. Age, pubertal stages, weight, BMI, fat mass and its percentage, waist and hip circumstance, waist to hip ratio, systolic and diastolic blood pressure, adiponectin, high sensitive C-reactive protein, triglyceride, total cholesterol, HDL and LDL-cholestrol, fasting blood sugar and insulin levels were measured. Data were analyzed by SPSS software. Results: The adiponectin levels were higher in normal weight adolescents (435.04±37.66 vs 411.46±34.47). There were a significant negative correlation between adiponectin levels with TG, total cholesterol, LDL-chol, Hs-CRP, insulin, weight, BMI, waist and hip circumstance, WHR, FM & FM percentage in obese group, however, the correlation between adiponectin and HDL-chol was positive. Conclusion: The higher adiponectin levels in normal weight group and significant negative correlation between FBS, insulin and lipid profile (except HDL-chol) and anthropometric index such as weight, BMI, WC, HC. WHR, FM & FMP in obese group can show the possibility of using adiponectin to prevent obesity outcome and improving healthy adolescents.